Platelet-rich plasma (PRP) is blood plasma that has been enriched with platelets. As a concentrated source of autologous platelets, PRP contains (and releases through degranulation) several different growth factors and other cytokines that stimulate healing of bone and soft tissue.
Blood-derived Growth Factors: Your blood contains life-giving fundamental, autologous (from your own body) growth factors, and growth-factors are essential to rebuilding new cells. Treatment with PRP utilizes a cutting-edge technology specifically designed to harvest and extract the growth-factor rich plasma from your own blood. With a fairly quick and simple process, Dr Elahi and his staff, are able to derive a high concentration of nutrient-rich cells, and create autologous platelet-rich plasma. PRP Extraction A small amount of blood similar to what is required for a basic lab test . The blood will be placed into a special centrifuge and spun at very rapid speeds to separate the platelets from the other components of the blood. Then, the platelet-rich plasma is activated to release at least 8 essential growth factors and signaling proteins. Platelet-rich plasma is a technology that deploys aspects of blood based biochemistry. Because all materials contained within PRP are exclusively from the patient (autologous in origin), there is virtually no risk of an allergic reaction or intolerance. Nevertheless, before any treatment, all medications you are taking (including herbs), as well as any medical history should be discussed with your provider. Growth Factor Production Known Effects:
Epidermal Growth Factor (EGF): Plays a significant role in the regulation of cell growth, proliferation, and differentiation during the remodelling phase. Stimulates keratinocyte and fibroblast production.
Transforming Growth Factor (TGF): Promotes angiogenesis, which is the physiological process involving the growth of new blood vessels which carry oxygen and various other nutrients to the cells.
Vascular Endothelial Growth Factor (VEGF): An important signaling protein involved in both vasculogenesis, the growth of blood vessels from existing vasculature, and angiogenesis.
Fibroblast Growth Factor (FGF): Promotes angiogenesis, granulation, and epithelialization, used for the intricate process of the skin repairing itself after injury.
Platelet-derived Growth Factor (PDGF): Attracts macrophages and fibroblasts to the zone of injury. Promotes collagen growth, “cleaning up” of old or damaged cells, and proteoglycan synthesis.
Interleukins, Macrophages, Keratinocytes, Endothelial Cells, Lymphocytes, Fibroblasts, Osteoblasts, Basophils, Mast Cells: Activates fibroblast differentiation. Induces collagen and proteoglycan synthesis for healthy cell production, and repair of damaged tissues.
Collagen Stimulating Growth Factor: Stimulates granulocyte and macrophage proliferation for the growth of healthy tissue and blood cells.
Keratinocyte Growth Factor (KGF): Keratinocyte migration, differentiation, and proliferations directly enhance wound healing and the generation of new skin.